Restarting a new game is not needed, as this mod will replace your current NPCs, It will not affect named NPCs females because I didn’t want to risk breaking anyone’s game or a quest that involved a woman (such as obtaining Bunker Hill as a settlement by talking to the woman in charge). Male Take Over, or MTO, is a mod that changes all generic, un-named NPCs into men, just like Skyrim’s Masculinized Level Lists mod.